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KMID : 1149220190270010001
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Korean Journal of Oriental Medical Prescription
2019 Volume.27 No. 1 p.1 ~ p.6
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Effects of Sansachunghyul-tang (SCT) on blood cholesterol levels in Triton WR1339-induced hyperlipidemic rats
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Chang Mun-Seog
Joo Seung-Hun
Kim Eun-Yi
Park Seong-Kyu
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Abstract
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Objectives : Sansachunghyul-tang (山?淸血湯) is a new formula consist of some herbs to treatment of hyperlipidemia. The lipid-lowering effects of the water extract of Sansachunghyul-tang (SCT) were examined using Triton WR1339-induced hyperlipidemic rats.
Methods : Hyperlipidemia was induced by intravenous injection of Triton WR1339 (tyloxapol) at 200 mg/kg body weight. Four groups of experimental animals were used: normal, control, and two sample groups. Sample groups were injected with SCT (100 and 1000 mg/kg) for 7 days.
Results : SCT produced statistically significant lowering effects on levels of total cholesterol (81.8 and 83.1%, p < 0.01, respectively), triglyceride (88.9 and 93.4%, p < 0.01, respectively), and phospholipid (86.7 and 94.3%, p < 0.01, respectively) than the control group. Taken together, SCT improved parameters of the HDL-cholesterol and LDL-cholesterol levels.
Conclusions : In conclusion, These results suggest that SCT could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.
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KEYWORD
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Hyperlipidemia, Sansachunghyul-tang (SCT), Triton WR1339
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